Prof. Eli Sprecher
Medicine
Oscillating between bedside and the bench, our research program is substantiating a major goal of our division, the integration of research and clinical care to the benefit of our patients. Our research program's main objectives are:
- Delineation of the genetic basis of inherited skin disorders using a palette of analytical tools.
- Systematic investigation of the function of novel genes found to be associated with inherited skin diseases using humanized models such as three-dimensional artificial skin equivalents, hair organ cultures and chimeric mice.
- Translation of this new knowledge into treatments for rare and more common diseases using engineered reporter cell lines and robotic small molecule library screening followed by in vitro and in vivo validation of relevant hits.
Medicine
- School of Medicine
The Lab recruiting students for projects in the field of molecular and applied genetics of skin diseases. The projects include many diverse work methods including work with 3 dimensional artificial skin models and hair (in-vitro & ex-vivo), bioinformatic analysis of complex genetic information and scanning libraries of small molecules.
Examples of the several activity programs in our laboratory around these principles:
- Deciphering the molecular basis of hereditary skin disorders resulting from abnormal epidermal differentiation
- Defining the genetic basis of pemphigus vulgaris, a life-threatening autoimmune condition that is particularly common among Jews, and translating this knowledge into new therapeutic strategies.
- Discovery of new anti-inflammatory substances capable of increasing the activity of SAMD9 or regulating CARD14 expression, two molecules previously found to be involved in the pathogenesis of hereditary inflammatory diseases
- Delineating the molecular basis and mechanism of action of damaged molecules in genetic hair diseases and translating this knowledge into new therapeutic strategies.
- Deciphering the molecular basis of hereditary skin disorders resulting from abnormal adhesion of cells in the skin.
- Identification of genetic and epigenetic factors of skin disease phenotypes.
- Develop a new skin-focused therapeutic strategy using patient-induced pluripotent stem cell technology.
Application Deadline: January 1, 2025
We are looking for medical students (MD) who want to do a third degree (PhD) or students after a master's degree. Experience in molecular biology and working with cell cultures, an advantage.
