Dr. Raya Sorkin
Exact Sciences
This ERC project aims to reveal the interplay between membrane tension and curvature and the organization and function of tetraspanin proteins. The context is specific key physiological scenarios: membrane fusion that occurs during viral infection and fertilization, and the formation of vesicles called migrasomes that mediate cellular communication.
Exact Sciences
- School of Chemistry
You will develop and use membrane model systems such as micro-beads coated with membranes of defined composition with incorporated proteins of interest, GUVs, and GPMVs. You will use single-molecule assays to study protein-membrane interactions, analyze data using custom-written python scripts, and use theoretical models for data interpretation in collaboration with theorists.
Our lab is equipped with state-of-the-art instrumentation for single-molecule mechanical studies. We are a collaborative and supportive group, and we will provide you will the needed training and support for your personal development. We are affiliated with the Center for the Physics and Chemistry of Living Systems at Tel Aviv University which provides a most stimulating environment for biophysical research by bringing together groups from various disciplines that study biophysical problems through a wide range of approaches. The campus is located north of Tel Aviv, a fun and vibrant city with an international atmosphere.
Application Deadline: March 15, 2023
For this interdisciplinary project, we look for a trained experimentalist with a strong research record in biophysics or soft matter, preferably with prior experience with microscopy and/or force-spectroscopy. Ph.D. in biophysics, physics, chemistry, molecular biology, or a related field is required.
